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Novus Biologicals
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Image Search Results
Journal: JCI Insight
Article Title: Inhibition of cell surface GRP78 and activated α 2M interaction attenuates kidney fibrosis
doi: 10.1172/jci.insight.183998
Figure Lengend Snippet: ( A ) Schematic outline of the study. Created in BioRender. Trink, J. (2025) https://BioRender.com/2rod2yk ( B ) Fα2M significantly reduced fibrosis measured as trichrome, PSR, and fibronectin, as well as the myofibroblast marker α–smooth muscle actin (α-SMA). ( C ) Treatment with Fα2M also prevented Smad3 and FAK activation (measured by phosphorylation at S473/475 and Y397, respectively), as well as increased YAP expression compared with control IgG1 ( n = 7–9; * P < 0.05, ** P < 0.01, **** P < 0.0001; # P < 0.05 significant by t test; scale bar represents 20 μm).
Article Snippet: Three separate studies were conducted: (a) treatment with C38 (made in-house) or the
Techniques: Marker, Activation Assay, Phospho-proteomics, Expressing, Control